Leonard Shelby can't make new memories. He can remember everything up until the night that his wife was murdered, but everything that happens after fades within a few minutes. Ever since that night, Leonard has been searching for the man that killed his wife, John G.

Leonard wakes up in a motel room and receives a phone call. 5 hours later, Leonard pulls up to a tattoo parlor with information that could enable him to finally track down John G and get revenge. The two plotlines proceed chronologically in parallel until they both culminate in a shocking conclusion.

The movie in chronological order, but this time as a real movie.