During an assignment to take down a new arms dealer in Miami, Sonny Crockett runs into a ghost from his past which sends him spiralling down a path of regret and darkness. As his focus on the case slips, he becomes involved with a mysterious femme fatale, a person he knows is playing him but lets her anyway. Crockett goes on a personal voyage, questioning his motives, morality and existence in what are widely considered to be the best episodes of the original show.

The Vice squad has a new commanding officer, Lieutenant Martin Castillo, a tough ex-DEA with a dark past. Crockett and Tubbs stumble upon a plot to heist a hotel vault and attempt to intervene, leading to the discovery of a much larger and more dangerous criminal enterprise involving an old nemesis of Castillo's from his days in the Golden Triangle drug zone. The Vice team is quickly forced into a game of cat-and-mouse with a deadly foe.

Miami Beach, 1984. Colombian drug kingpin Calderone is ruthlessly seizing territory, eliminating all competitors in a series of violent murders. Miami Vice Detective Sonny Crockett is assigned to take down the drug lord but is faced with double-crosses, assassination and incompetence at every turn. Enter Ricardo Tubbs, a stranger from New York who has a personal vendetta against Calderone. Crockett and Tubbs are forced into an unlikely alliance that will take them from the sandy shores of Miami to the clear waters of the Bahamas in a hunt for Calderone, full of danger, death and pastel suits.