Hey I got MakeMKV working, thanks for your assistance, and I got a blueray of Marley & Me, can you tell me what are the appropriate settings for handbrake to not loose quality? I did a test rip and set it so high it wont even play, LOL. Could really use assistance!
Don't try to edit the ripped MKV files. Get TSMuxerGUI (it's free) and demux the audio and video streams from the MKV file. The video will be .TS or .M2TS and the audio can be dealt with separately. You can take the audio stream and open it in Audacity (also free) and export each track (2 if stereo or 6 if surround) into individual wav files or into merged wav files. If you're already doing this or the same with different software, good.
If you are using a video editor that allows proxy files, you can look up how to create them in your particular editor. That would keep your original rips but would create a lower quality file for smoother playback while editing. Editing bluray ".TS" or ".M2TS" files in Adobe Premiere, in my experience editing on a pretty good laptop, this is absolutely necessary. You may need to use your video editor program to create the proxy files in order to link them properly.
If your editor doesn't allow that, then maybe you can try doing something similar manually starting with Handbrake, but I would recommend the other way first.
If that doesn't work, then, and only then:
In Handbrake, you want to make sure the tab with deinterlacing and decombing and whatnot has all those filters off. Make sure the tab with cropping isn't auto cropping anything you don't want it to (four 0's, top, bottom, left, right, means it's not cropping), then the important tab is the one with frame rate and video quality. On this tab, choose one of the HD file output presets, maybe HD for Web or something. Then change the framerate from a set 30 or 60 or whatever to instead be "Same as source". Make sure it's constant framerate, not variable framerate. Accidentally making it variable framerate means it's not actually the same framerate the source video is and this will cause problems later. If you want to be 100% certain, you can choose the film framerate of 23.976fps, but I recommend just using "Same as source". The bitrate should be using the quality dial, and you can turn the number down for less compression or up for lower file size. Between 18 and 24 is recommended for something deliverable, but if you are making something for easy playback, you can probably crank it to 25ish without it being detrimental for your editing experience. The output dimensions I would recommend halving. It's naturally 1920x1080 so half it to 960x540. This will considerably lower the file size and without losing too much quality to tell what's happening. You can then check the other settings, make sure they're to your liking, and export when you're ready.
Then enjoy editing the lower quality easier to play file. And when you are finished editing, before you export, the tricky part. You have to trick your video editor to accept the original file in place of the lower quality file. You can look up how to replace video source files in your editor program of choice. It's a simple right click in Adobe, I'm not sure about other programs. There may be an issue with the halved dimensions depending on your editor, or to avoid this, skip the halving step and just crank the quality down further in Handbrake.